About Our Research

Insects are obligatory hosts for many parasites. These parasites must overcome insect innate immunity and undergo development before being transmitted. However, the detailed genetic basis and molecular mechanisms of parasite infection in insects are not fully clear. We are using the Anopheles gambiae mosquito and Plasmodium falciparum parasite interaction system to address these fundamental knowledge gaps.

Opportunities for postdoctoral fellows, graduate and undergarduate research assistantship are available.

Annotation and HapMap

A genome browser for Anopheles gambiae for the predicted genes, alternative splicing, short sequence reads, SNPs and linakge disequilibrium from this lab. In addition, other external knowledge databases such as EST, gene ontology, NCBI, Vectorbase are also be integrated.

Association Studies

We developed an approach to fine-map large genomic regions that play important roles for malaria parasite resistance in the vector mosquito, Anopheles gambiae. Direct-association studies in wild mosquitoes identified three mutations in three genes that are associated significantly with Plasmodium falciparum infection.

Functional Analysis

Molecular biology and biochemistry approaches are used to analyze the functions of important genes from Anopheles gambaie and from P. falciparum in the lab and in the wild in Africa.