Mosquitoes transmit many diseases inclduing degue fever, zika virus, and malaria. Malaria alone causes more than 200 million clinical cases and kill half million a year worldwide. Malaria pathogens are Plasmodium parasites. Inhibiting pathogen development in mosquitoes will block the disease transmission. My research aims to find target genes that are essential for pathogen transmission in mosquitoes. Then we develop vaccines and drugs targeting these critical pathways to stop disease transmission.
Drawing of FREP1-mediated Plasmodium invading mosquito pathway.
Investigating molecular mechanisms of malaria transmission to mosquitoes.
supported by Career Award from National Science Foundation ( NSF 1742644 ).
Fungal metabolites block malaria transmission.
Supported by National Institute of Allergy and Infection Diseases, National Institite of Health (1 R01 AI125657)
Develop malaria transmission blocking vaccines.
Supported by National Institute of Allergy and Infection Diseases, National Institite of Health (7 R21 AI115178)